Nerdy video game developer Miles (Daniel Radcliffe) is a little too fond of stirring things up on the internet with his caustic, prodding, and antagonizing comments. One night, he makes the mistake of drunkenly dropping an inflammatory barb on a broadcast of Skizm, an illegal death-match fight club streamed live to the public. In response, Riktor (Ned Dennehy), the maniacal mastermind behind the channel, decides to force Miles' hand (or hands, as it were) and have him join the "fun." Miles wakes to find heavy pistols bolted into his bones, and learns Nix (Samara Weaving), the trigger-happy star of Skizm, is his first opponent.